This study aimed to screen the presence of phytohemagglutinin for ABO blood groups from 20 plant species found in Puerto Princesa City, Palawan. The presence of antibacterial potential was also screened from those which agglutinated one, two, three and four blood types. The agglutination of blood types A, B, AB and O after application with each of the leaf crude extracts was examined macroscopically and microscopically. There were two trials conducted per treatment per leaf extract. Among the 20 plant species tested, 14 (70%) showed agglutination with at least one blood type while 6 (30%) species did not exhibit agglutination. Two species, the Palawan Pitcher Plant Nepenthes palawanensis and Cashew Anacardium occidentale L. agglutinated with all blood types. Four species were found to have the capability of determining a specific blood type: Atsuete (Bixa orellana L.) and Ilang-ilang (Cananga odorata Lam.) for blood type O; Balayong (Cassia nodosa Roxb.) for blood type A; and Makabuhay (Tinospora reticulata Miers.) for blood type AB. Cashew, Palawan gabi (Colocasia sp. Schott), Atsuete and Makabuhay leaf extracts were tested for antibacterial potential against Escherichia coli, Staphylococcus aureus, Bacillus cereus, Bacillus megaterium, Bacillus subtilis and Pseudomonas aeruginosa. Among the four plants tested, Makabuhay showed antibacterial effects to five bacterial species (E. coli, S. aureus, B. cereus, B. megaterium and B. subtilis), followed by Atsuete to four bacterial species (S. aureus, B. cereus, B. subtilis and B. megaterium). Cashew showed only inhibitory effects toward two bacteria (S. aureus and B. megaterium) while Palawan gabi did not inhibit any of the six bacterial species. None of the four extracts inhibited P. aeruginosa.